International Conference on Neuro Oncology and Brain Tumor July 21-22, 2016 Brisbane, Australia

Brain Cancer market is segmented on the basis of diagnosis and therapeutics. A brain cancer involves the growth of abnormal cells in the tissues of the brain. Primary brain cancer involves malignant tumor, Brain stem tumors, germ cell tumor, pituitary adenomas, Tumor development, DIPG, Cellular biology of brain cancer, primary CNS lymphomas, Pathophysiology and Risk factors of brain cancer and prognosis of brain tumors.

In 2011, 1,724 brain cancers were diagnosed in Australia. The risk of being diagnosed with a brain cancer by age 85 is 1 in 96 for men and 1 in 149 for women. In 2012, there were 1241 deaths in Australia caused by brain cancer.

Key market players which make a part in this field are Antisense Pharma, Novartis AG, AstraZeneca, Bristol-Myers Squibb, Pfizer Inc., Hoffmann-La Roche Ltd, Genentech and others

Glioblastoma multiforme (GBM) (named as glioblastoma) is a invasive glioma which is developed from star-shaped glial cells (i.e. astrocytes and oligodendrocytes) that support the health of the nerve cells within the brain. Almost 1 in 5 tumors in the brain are glioblastoma.

Glioblastoma multiforme occur most often in adults between the ages of 45 and 70 years. This tumor represents about 15.4% of all primary brain tumors and about 60-75% of all astrocytomas. They increase in frequency with age, and affect more men than women. Only three per cent of childhood brain tumors are glioblastoma

When cancer develops elsewhere in the body and spreads (metastasizes) to the brain, which is called as secondary brain tumor, or metastatic brain cancer. Brain metastases (secondary brain tumors) occur in approximately 15% of cancer patients as a result of haematogenous dissemination of cancer, and the incidence may be rising because of better control of systemic disease. 

The overall annual incidence of primary brain tumors in the United States is 9.5 cases per 100,000 population. Over 60% of primary brain tumors are gliomas, and at least two-thirds of these are clinically aggressive and high grade. Brain tumors represent 20% of all childhood malignancies and are the number two cause of cancer death in children after leukaemia

Angiogenesis plays a critical role in the growth and spread of cancer, it also plays a major role in the transition of tumors from a benign state to a malignant (cancerous), leading to the use of angiogenesis inhibitors in the treatment of cancer.

Angiogenesis is a vital process that facilitates tumor growth and survival. Angiogenesis is a well-controlled process that is regulated by angiogenic, growth, and survival factors that are secreted by the malignant cells as well as other cells within the tumor microenvironment.

Radiation Oncology encompasses all aspects of research that impacts on the treatment of cancer using radiation. It discloses findings in molecular and cellular radiation oncology, radiation technology, radiation physics, and clinical oncology.

Radiation Oncology is made up of three unique medical specialties that focus on the treatment of cancer patients with radiotherapy treatment (also known as radiation therapy); namely Radiation Oncologists, Radiation Therapists and Radiation Physicists

The primary method which is used in the initial diagnosis, monitoring of response, and process of progression in Neuro-oncology is neuroimaging techniques. Neuro imaging has enabled great progress in the diagnosis of brain cancer, as well as finding useful application in medical research and practice.

There are a number of accepted, safe imaging techniques in use today in research facilities and hospitals throughout the world which includes FMRI, CT scan, PET, EEG, MEG, NIRS. This session includes latest technologies and developments of Structural and functional imaging, Biomarker Discovery, Radioactive compounds in Neuroimaging, Computed tomography, Diffuse optical imaging, Magnetic resonance imaging, Positron emission tomography.

About one-third of patients are being treated for cancer pain, which leads to many different forms. It may be short-lived or long-lasting, mild or severe, or effect on few organs, bones or organ system. Since each patient’s pain is unique, it is determined that cancer pain management treatment plans must be adapt to address individual needs.

Pediatric Neuro-oncology is a fast developing field. Brain tumors are the cause of cancer-related deaths among children. Brain disorders are the most common solid malignancy in children.  Their bodies and brains are still developing. Their tumors are different.  The common childhood brain cancers are not the same as the most common adult brain cancers. Though they are rare, brain tumors are very common form of solid tumors among children under the age of 15 and represent about 20% of all childhood cancers. 

Childhood tumors frequently appear in different locations and behave differently than brain tumors appearing in adults.  Treatment options are different and can be strongly influenced by the age of the child.  Children suffering from brain cancer may also have a much better prognosis than adults with a similar condition. The common types of brain tumors in children are Neurofibromatosis, Primitive Neuroectodermal tumor, Leukaemia, Neuroblastoma, Medulloblastoma, Ependymoma and Astrocytoma.

Neurosurgery is a complex surgical procedure that involves treatment, diagnosis, and rehabilitation of disorders affecting any region of the nervous system.

Some of the most common Neurosurgeries are skull base surgery, Image Guided Surgery, Laser Surgery ,  spinal Neurosurgery and  Neurosurgical treatment. The Global Neurosurgery market is expected to grow 11.71% over the period of 2014-2019.

Neurosurgery session includes Image Guided Surgery, Laser Surgery, Surgical management for brain tumors, spinal neurosurgery, skull base surgery, Neurosurgical treatment, Geriatric Neurosurgery, latest innovations and techniques

The work of the neuropathologist consists largely of examining biopsy tissue from the brain and spinal cord to aid in diagnosis of disease. The biopsy is usually requested after a mass is detected by radiologic imaging. As for autopsies, the principal work of the neuropathologist is to help in the post-mortem diagnosis of various forms of dementia and other conditions that affect the central nervous system.

Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole autopsies. Neuropathology is a subspecialty of anatomic pathology, neurology, and neurosurgery.

Brain cancer market is segmented on the basis of diagnosis and therapeutics.  Major research is going on targeted Therapies for Brain Cancer. On the basis of treatment the market is segmented into surgeries, radiation therapy, immunotherapy, chemotherapy, and targeted therapy. Therapeutic approaches include Chemotherapy Intensity modulated radiation therapy, palliative care, vaccine therapy, surgical delivery, Molecular pathology for clinician and challenges in therapy.

Tumour heterogeneity relate differences between tumours of the same type in different patients, and also difference between cancer cells within a tumour cells can show distinct  including cellular morphology, motility, gene expression, proliferation, metabolism, and metastatic potential. This process occurs both between tumours which is called as inter-tumour heterogeneity and within tumours called as intra-tumour heterogeneity. It plays a major role in brain Cancer.

Genetic and epigenetic differences between cancer cells within a tumour might explain why some tumour cells remain present in the patient even after cancer treatment has finished. Most current efforts are focused on understanding heterotypic interactions between tumor cells and surrounding normal cells, which is known about the interactions between and among heterogeneous tumor cells within a neoplasm. Tumor Heterogeneity covers Inter- intra tumour heterogeneity, Cancer Stem Cells, Brain Tumor Microenvironment, Experimental- Sequencing, Genetic Heterogeneity and Implications and challenges

Brain Cancer clinical trials are research studies that test new and better ways to prevent, diagnose and treat Brain cancer. A world-first human trial has been set to begin in Brisbane and Melbourne has the potential to be one of the biggest breakthroughs in the treatment of brain cancer, researchers say. According to the Cure Brain Cancer Foundation worth of $500,000 provided to the study over the next three years.

The Centre for Neuro-Oncology offers the latest advances in care for adult patients with brain tumors or spinal cord tumors, as well as for neurologic complications of brain cancer and its treatments. The Australian Government is supporting Australia’s capacity to develop industry-independent cancer clinical trials.