Neuro-Oncology and Brain Tumor

Tumour Heterogeneity

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Tumour heterogeneity relate differences between tumours of the same type in different patients, and also difference between cancer cells within a tumour cells can show distinct  including cellular morphology, motility, gene expression, proliferation, metabolism, and metastatic potential. This process occurs both between tumours which is called as inter-tumour heterogeneity and within tumours called as intra-tumour heterogeneity. It plays a major role in brain Cancer.

Genetic and epigenetic differences between cancer cells within a tumour might explain why some tumour cells remain present in the patient even after cancer treatment has finished. Most current efforts are focused on understanding heterotypic interactions between tumor cells and surrounding normal cells, which is known about the interactions between and among heterogeneous tumor cells within a neoplasm. Tumor Heterogeneity covers Inter- intra tumour heterogeneity, Cancer Stem Cells, Brain Tumor Microenvironment, Experimental- Sequencing, Genetic Heterogeneity and Implications and challenges